Workshop A | Tuesday, January 28
9:00am - 12:00pm

Examining the Biology of the DNA Damage Response & Targeted Therapeutics

• Understanding the mechanisms of DNA Damage and repair


• Methods and challenges in investigating the DDR network and understanding interacting partners


• Understanding the tumor microenvironment and its role in the DDR
• What can models teach us?


• Identifying biomarkers for use in the clinic


• Constructing combination strategies to broaden the application of DDR agents


• Designing clinical trials to test agents for novel targets



junjie chen
tim yap




Junjie Chen
Professor, Experimental Radiation Oncology
MD Anderson CancerCenter


Timothy A. Yap
Associate Professor, Investigational Cancer Therapeutics
MD Anderson Cancer Center

Workshop B | Tuesday, January 28
1:00pm - 4:00pm

Computational Techniques for DDR Therapeutic Development

• Understanding the therapeutic implication of mutational signatures or genomic scars for DNA repair deficiency


• Genomic characterization and interpretation of homologous recombination deficiency signatures


• Subtypes and transcriptome projection for biomarker discovery and patient selection


• Synthetic lethal discovery exploiting cancer dependency

Jaegil Kim




Jaegil Kim
Senior Principle Scientist
Tesaro: a GSK Company