Tim J. Wigle

Tim J. Wigle

Company: Ribon Therapeutics

Job title: Director, Molecular Discovery


A Bespoke Screening Platform to Study Mono(ADP-ribosylation) 10:30 am

PARP enzymes deposit mono(ADP-ribosylation) or poly(ADP-ribosylation) on their substrate proteins Resulting ADP-ribosylation is involved in cellular signaling in processes such as cellular stress response, protein homeostasis and immunology/inflammation Developed BEACON+ platform to enable drug discovery for monoPARP enzymes that does not rely on knowledge of the substrates for each enzyme, which are poorly understood Screening…Read more

day: Day One

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